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Animal Science Faculty

Jonathon Green

Jonathan A. Green

Associate Professor

163 Animal Science Research Center
Division Of Animal Sciences
Columbia, MO 65211
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  • Curriculum Vitae


  • Idaho State University, College of Arts and Sciences, Pocatello, ID

    Bacholor of Science in Biochemistry, 1991.
  • University of Missouri-Columbia, College of Agriculture, Food and Natural Resources, Columbia, MO

    Doctor Of Philosophy in Biochemistry, 1997.


  • Graduate research assistant; University of Missouri-Columbia
    Department of Biochemistry, 9/91-12/97.
  • Post-doctoral fellow; University of Missouri-Columbia
    Department of Animal Sciences, 1/98-2/99.
  • Research Assistant Professor; University of Missouri-Columbia
    Department of Animal Sciences, 3/99-8/01
  • Assistant Professor; University of Missouri-Columbia
    Department of Animal Sciences, 9/01-8/08
  • Associate Professor; University of Missouri-Columbia
    Department of Animal Sciences, 9/08-present

Ad Hoc Reviewer

Animal Genetics; Animal Reproduction Science; Biology of Reproduction; BMC Genomics; Cell and Tissue Research; Journal of Molecular Evolution; Molecular Reproduction and Development; Physiological Genomics; Placenta; Proceedings of the National Academy of Science; Proteomics; Reproduction; Reproduction, Fertility and Development; Reproduction-Nutrition-Development; Reproductive Biology; Theriogenology

Ad Hoc Grant Reviewer

USDA-NRI; USDA-SBIR; NSF; Health Research Board, Ireland; The Welcome Trust, UK.; United Federation of Animal Welfare (UFAW)
MU Research Board; MU Ag Experiment Station


  • Co-instructor for Gamete and Embryo Development (AnSci 9433; F02, F04, F06)
  • Co-instructor for Animal Science Laboratory Practicum (AnSci 1065; F05 to present)
  • Instructor for Placenta-Maternal Interactions during Pregnancy (AnSci 9001; Spr08)


Refereed Articles

Telugu BPVL, Palmier MO, Van Doren SR, Green JA (2010). An Examination of the Proteolytic Activity for Bovine Pregnancy-Associated Glycoprotein 2 and 12. Biological Chemistry (In Press)

McGlasson DL, Green JA, Stoecker WV, Babcock JL, Calcara DA (2009). Duration of Loxosceles reclusa venom detection by ELISA from swabs. Clinical Laboratory Science 22:216-222.

Wasserman GS, Calcara DA, Green JA, Stoecker WV, Larkin KE (2009). Systemic loxoscelism confirmed by bite-site skin surface ELISA [CASE STUDY] Missouri Medicine Nov-Dec;106(6):425-427, 431.

Bovine Genome Consortium (2009). The Genome Sequence of Taurine Cattle: A window to ruminant biology and evolution. Science 324:522-527.

Sullivan TM, Micke GC, Magalhaes RS, Martin GB, Wallace CR, Green JA, Perry VEA (2009). Dietary protein during gestation affects hormonal indicators of placental function and fetal development in heifers. Placenta 30:348–354

Telugu BPVL, Walker AM, Green JA (2009). Characterization of the Pregnancy-Associated Glycoprotein gene family in the bovine genome. BMC Genomics 10:185

Egen TE, Ealy AD, Landon LA, Roberts RM, Green JA (2009). Suppression of circulating ovine Pregnancy-Associated Glycoproteins does not substantially impact pregnancy. Animal 3:850–857

Whitworth KM, Li R, Spate LD, Wax DM, Rieke A, Whyte JJ, Manandhar G, Sutovsky M, Green JA, Sutovsky P, Prather RS (2009). Method of oocyte activation affects cloning efficiency in pigs. Mol Reprod Dev 76:490-500

Telugu BPVL, Spate L, Prather RS, Green JA (2009). Acid peptidase activity released from in vitro produced porcine embryos: a candidate marker to predict developmental competence. Mol Reprod Devel 76:417–428.

McHughes CE , Springer GK, Spate L, Li R, Woods R, Green M, Korte SW, Murphy CN, Green JA, Prather RS (2009) Identification and quantification of differentially represented transcripts in preimplantation bovine embryos. Mol Reprod Dev 76:48-60.

Telugu BPVL, Green JA (2008). Characterization of the Peptidase Activity of Recombinant Porcine Pregnancy-Associated Glycoprotein-2. J Biochemistry 144:725–732

Green MP, Spate LD, Parks TE, Kimura K, Murphy CN, Williams JE, Kerley MS, Green JA, Keisler DH, Roberts RM (2008). Nutritional skewing of conceptus sex in sheep: effects of a maternal diet enriched in rumen-protected polyunsaturated fatty acids (PUFA). Reprod Biol Endo 6:21.

Rankin WV, Henry CJ, Turnquist SE, Turk JR, Beissenherz ME, Tyler JW, Green JA. (2008) Comparison of distributions of survivin among tissues from urinary bladders of dogs with cystitis, transitional cell carcinoma, or histologically normal urinary bladders. Am J Vet Res 69:1073-1078.

Rankin WV, Henry CJ, Turnquist SE, Turk JR, Beissenherz ME, Tyler JW, Rucker EB, Knapp DW, Rodriguez CO, Green JA (2008). Identification of survivin, an inhibitor of apoptosis, in canine urinary bladder transitional cell carcinoma. Vet Comp Oncology 6:141-150.

Brandt GA, Parks TE, Killian G, Ealy AD, Green JA (2007). The cloning and expression analysis of Pregnancy-Associated Glycoproteins from the placenta of white-tail deer. Mol Reprod Devel 74:1355–1362.

Akdeniz S, Green JA, Stoecker WV, Gomez HF, Keklikçi SU (2007). Diagnosis of loxoscelism in two Turkish patients confirmed with an enzyme-linked immunosorbent assay (ELISA) and non-invasive tissue sampling. [CASE STUDY] Dermatol Online Journal 13(2):11.

Martin L, Besch-Williford C, Lai L, Cheong H-T, Im G-S, Park K-W, Murphy C, Hao Y, Ellersieck MR, Keisler DH, Schatten H, Green JA, Prather RS (2007). Morphologic and histologic comparisons between in vivo and nuclear transfer derived porcine embryos. Mol Reprod Devel 74:952–960.

Stoecker WV, Green JA, Gomez HF (2006). Diagnosis Of Loxoscelism In a Child Confirmed With An Enzyme-Linked Immunosorbent Assay (ELISA) and Non-Invasive Tissue Sampling. [CASE STUDY] J Am Acad Dermatol 55:888-890.

Chakrabarty A, MacLean II JA, Hughes AL, Roberts RM, Green JA (2006). Rapid Evolution of the trophoblast Kunitz domain proteins (TKDPs) – A multi-gene family in ruminant ungulates. J Mol Evol 63:274-282.

Chakrabarty A, Green JA, Roberts RM (2006). Origin and evolution of the TKDP gene family. Gene 373:35–43.

Echternkamp SE, Vonnahme KA, Green JA, Ford SP (2006). A Comparison of Concentrations of Vascular Endothelial Growth Factor and Pregnancy-Associated Glycoproteins in Maternal Blood between Cows Gestating Single versus Twin Fetuses. J Anim Sci 84:2057–2064.

Chen Y, Green JA, Antoniou E, Ealy AD, Mathialagan N, Walker AM, Avalle MP, Rosenfeld CS, Hearne LB, Roberts RM. (2006). Effect of Interferon-tau Administration on Endometrium of Non-Pregnant Ewes: a Comparison with Pregnant Ewes. Endocrinology. 147:2127–2137.


Perry GA, Smith MF, Lucy MC, Green JA, Parks TE, MacNeil MD, Roberts AJ, Geary TW (2005). Relationship between follicle size at insemination and pregnancy success. Proc Natl Acad Sci, USA 102: 5268-5273.

Wooding FBP, Roberts RM, Green JA (2005). Light and electron microscope immunocytochemical studies of the distribution of Pregnancy-Associated Glycoproteins (PAGs) throughout pregnancy in the cow: possible functional implications. Placenta. 26:807-827.

Whitworth KM, Agca C, Kim JG, Patel RV, Springer GK, Bivens N, Forrester LJ, Mathialagan N, Green JA, Prather RS (2005). Transcriptional Profiling of Pig Embryogenesis by Using a 15K Member Unigene Set Specific for Pig Reproductive Tissues and Embryos. Biol Reprod. 72:1437–1451.

Green JA, Parks TE, Avalle MP, Telugu BP, McLain AL, Peterson AJ, McMillan W, Mathialagan N, Xie S, Hook RR, Roberts RM (2005). The establishment of an ELISA for the detection of Pregnancy-associated glycoproteins (PAGs) in the serum of pregnant cows and heifers. Theriogenology. 63:1481–1503.

Whitworth KM, Springer GK, Forrester LJ, Spollen WG, Ries J, Lamberson WR, Bivens N, Murphy CN, Mathialigan N, Green JA, Prather RS (2004). Developmental expression of 2,489 genes during pig embryogenesis: an Expressed Sequence Tag project. Biol Reprod. 71:1230–1243.

Maclean JA, Roberts RM, Green JA (2004). Atypical Kunitz-type proteinase inhibitors produced by the ruminant placenta. Biol Reprod. 71:455-463.

Hughes AL, Green JA, Piontkivska H, Roberts RM (2003). Aspartic Proteinase Phylogeny and the Origin of Pregnancy-Associated Glycoproteins. Mol Biol Evol. 20:1940-1945.

Tuggle CK, Green JA, Fitzsimmons C, Woods R, Prather RS, Malchenko S, Soares BM, Kucaba T, Crouch K, Smith C, Tack D, Robinson N, O'Leary B, Scheetz T, Casavant T, Pomp D, Edeal JB, Zhang Y, Rothschild MF, Garwood K, Beavis W (2003). EST-Based Gene Discovery in Pig: Virtual Expression Patterns and Comparative Mapping to Human. Mammalian Genome. 14:565-579.

Maclean JA, Chakraborty A, Xie S, Bixby JA, Roberts RM, Green JA (2003). A family of Kunitz proteins from trophoblast: Expression of the trophoblast Kunitz domain proteins (TKDP) in cattle and sheep. Mol Reprod Devel. 65:30-40.

Chen X, Rosenfeld CS, Roberts RM, Green JA (2001). An aspartic proteinase expressed in the yolk sac and neonatal stomach of the mouse. Biol Reprod 65:1092-1101.

Szafranska B, Miura R, Ghosh D, Ezashi T, Xie S, Roberts RM, Green JA (2001). The gene for porcine pregnancy-associated glycoprotein 2: Its Structural organization and analysis of its promoter. Mol Reprod Dev 66:137-146.

Shi XW, Fitzsimmons CJ, Genet C, Prather R, Whitworth K, Green JA, Tuggle CK (2001). Radiation hybrid comparative mapping between human chromosome 17 and porcine chromosome 12 demonstrates conservation of gene order. Anim Genet 32:205-209.

Do HJ, Kim JH, Abeydeera LR, Han YM, Green J, Roberts RM, Matteri RL, Day BN, Prather RS (2001) Expression of pregnancy-associated glycoprotein 1 and 2 genes in in vitro-, in vivo- and parthenogenetically-derived preimplantation pig embryos. Zygote 9:245-250.

Garbayo JM, Green JA, Mannekin M, Beckers J-F, Kiesling DO, Ealy AD, Roberts RM (2000) Caprine pregnancy-associated Glycoproteins (PAG): Their cloning, expression and evolutionary relationship to other PAG. Mol Reprod Dev 57:311-322.

Green JA, Xie S, Quan X, Bao B, Gan X, Mathialagan N, Beckers J-F, Roberts RM (2000) Pregnancy-associated glycoprotein exhibit spatially and temporally distinct expression patterns during pregnancy. Biol Reprod 62:1624-1631.

Hughes AL, Green JA, Garbayo JM, Roberts RM (2000) Adaptive diversification within a large family of recently duplicated, placentally-expressed genes. Proc Nat Acad Sci, USA 97: 3319-3323.

Ghosh D, Taylor JA, Green JA, Lubahn DB (1999) Methoxychlor stimulates estrogen-responsive messenger ribonucleic acids in mouse uterus through a nonestrogen receptor (non-ER)a and non-ERb mechanism. Endocrinology 140: 3526-3533.

Green JA, Xie S, Szafranska B, Gan X, Newman AG, McDowell K, Roberts RM (1999) Identification of a new aspartic proteinase expressed by the outer chorionic cell layer of the equine placenta. Biol Reprod 60:1069-1077.

Ealy AD, Green JA, Alexenko AP, Keisler DH, Roberts RM (1998) Different ovine interferon-tau genes are not expressed identically and their protein products display different activities. Biol Reprod 58:566-573.

Xie S, Green J, Bao B, Beckers J-F, Valdez KE, Hakami L, Roberts RM (1997) Multiple pregnancy-associated glycoproteins are secreted by day 100 ovine placental tissue. Biol Reprod 57:1384-1393.

Xie S, Green J, Bixby JB, Szafranska B, DeMartini JC, Hecht S, Roberts RM (1997) The diversity and evolutionary relationships of the pregnancy-associated glycoproteins, an aspartic proteinase subfamily consisting of many trophoblast-expressed genes. Proc Natl Acad Sci 94:12809-12816.

Xie S, Nagel RJ, Green J, Beckers J-F, Roberts RM (1996) Trophoblast-specific processing and phosphorylation of pregnancy-associated glycoprotein-1 in day 15 to 25 sheep placenta. Biol Reprod 54:122-129.

Guruprasad K, Blundell TL, Xie S, Green J, Szafranska B, Nagel RJ, McDowell K, Baker CB, Roberts RM (1996) Comparative modeling and analysis of amino acid substitutions suggests that the family of pregnancy-associated glycoproteins includes both active an inactive aspartic proteinases. Protein Eng 9:849-856.

Xie S, Green J, Beckers J-F, Roberts RM (1995) The gene encoding bovine pregnancy-associated glycoprotein-1, an inactive member of the aspartic proteinase family. Gene 159:193-197.

Szafranska B, Xie S, Green J, Roberts RM (1995) Porcine pregnancy-associated glycoproteins: new members of the aspartic proteinase gene family expressed in trophectoderm. Biol Reprod 53:21-28.


Green, JA (2004) Defining the function of a prolactin gene family member. Proc Natl Acad Sci, USA 101:16397-16398.

Reviews and Book Chapters (corresponding author only)

Telugu BP, Green JA (2007) Comparative Placentation. Veterinary Reproductive Biology; Chapter 12; Constantinescu G, Schatten H (eds.). Blackwell Publishing, Ames Iowa, USA

Green JA, Kim J-G, Whitworth KM, Agca C, Prather RS. (2006) The use of microarrays to define functionally-related genes that are differentially expressed in the cycling pig uterus. Control of Pig Reproduction VII. Eds. CJ Ashworth and RR Kraeling (Society of Reproduction and Fertility Supplement 62). Nottingham University Press, UK.

Green JA, Roberts RM (2006) Establishment of an ELISA for the detection of native bovine pregnancy-associated glycoproteins secreted by trophoblast binucleate cells. Methods in Molecular Medicine, Vol. 122: 321-330. Placental and Trophoblast Methods and Protocols, Vol 2; J.S. Hunt JS and Soares MJ (eds.), Humana Press, Inc. Totowa, NJ

Green J, Roberts RM (2004) Pepsin F. Handbook of Proteolytic Enzymes, 2nd ed, vol. 1, Chapter 37; pp137-138; Barrett AJ, Rawlings ND, Woessner JF (eds.), Elsevier Academic Press, London, UK.

Green JA, Xie S, Roberts RM (1998) Pepsin-related molecules secreted by trophoblast. Rev Reprod 3:62-69.

Green J, Xie S, Gan X, Roberts RM (1998) An aspartic proteinase expressed in the equine placenta. Aspartic proteinases, James MNG (ed.), Plenum Press, New York.

Green J, Xie S, Roberts RM (1998) Horse placental aspartic proteinase. Handbook of Proteolytic Enzymes, Barrett AJ, Rawlings ND, Woessner JF (eds.), Academic Press, London.

Reviews and Book Chapters (co-author)

Prather RS, Ross JW, Isom SC, Green JA (2009) Transcriptional, Post-Transcriptional and Epigenetic Control of Porcine Oocyte Maturation and Embryogenesis. Control of Pig Reproduction VIII. Eds. H Rodriquez-Martinez, JL Vallet and AJ Ziecic. Nottingham University Press, UK. Soc Reprod Fertil Suppl. 2009;66:165-76.

Prather RS, Sutovsky P, Green JA (2004) Nuclear remodeling and reprogramming in transgenic pig production. Exp Biol Med 229:1120-1126.

Roberts RM, Xie S, Green J (2004) Pregnancy-associated glycoproteins. Handbook of Proteolytic Enzymes, 2nd ed, vol. 1, Chapter 36; pp135-136; Barrett AJ, Rawlings ND, Woessner JF (eds.), Elsevier Academic Press, London, UK.

Roberts RM, Xie S, Green J (1998) Pregnancy-associated glycoproteins. Handbook of Proteolytic Enzymes; Barrett AJ, Rawlings ND, Woessner JF (eds.), Academic Press, London.

Technical Reports

Jiang H, Bivens NJ, Ries JE, Whitworth KM, Green JA, Forrester LJ, Springer GK, Didion BA, Mathialagan N, Prather RS, Lucy MC (2001) Constructing cDNA libraries with fewer clones that contain long poly(dA) tails. Biotechniques 31:38-42.

Proceedings Chapters

Telugu BP, Wooding FBP, Roberts RM, Green JA (2005). Pregnancy-associated glycoproteins: A complex family of trophoblast genes expressed by the ungulate placenta. Maternal Recognition of Pregnancy in the mare III. P41-43. Strout TAE and Wade JF, Eds. Havemeyer Foundation Monograph, Series No. 16. R and W communications, UK. Proceedings held 13-16 November 2004.

Whitworth K, Springer GK, Forrester LJ, Spollen WG, Ries J, Murphy CN, Mathialagapan N, Didion BA, Green JA, Prather RS (2003) Characterization of cDNA libraries developed from porcine oocytes and embryos to determine differential expression patterns. Mammalian Embryo Genomics, P29-36. First International Meeting on Mammalian Embryo Genomics, Québec City, July 20, 2002.

Green JA, Xie S, Chen X, Rosenfeld CS, Roberts RM (1999) Pregnancy-associated glycoproteins – structural and functional diversity among species. Feto-maternal control of pregnancy. P20-21. TAE Stout and JF Wade, Eds. Havemeyer Foundation Monograph, series No. 2. Barbados, West Indies, Nov. 14-16, 1999.