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Animal Science Faculty

David Conant

Gavin Conant


Assistant Professor

Bioinformatics

163B Animal Science Research Center
Division Of Animal Sciences
Columbia, MO 65211

Education


B.S. Biology summa cum laude, 1998, The University of New Mexico.  Thesis title: “Effects of nucleotide composition bias on the success of the parsimony criterion in phylogenetic inference.”  Advisor: Prof. Paul Lewis

Ph. D. Biology, with distinction, 2004, The University of New Mexico. Dissertation title: “Functional divergence at the molecular level: Robustness, asymmetry, and convergence.”  Advisor: Prof. Andreas Wagner.

Positions Held:

September 2008-present: Assistant Professor, Division of Animal Sciences, University of Missouri-Columbia, Columbia, Missouri.
January 2005-July 2008: Post-doctoral fellow, Smurfit Institute of Genetics, Trinity College, Dublin, Ireland.  Supervisor: Prof. Kenneth Wolfe.
June-Dec. 2004: Post-doctoral fellow, Lehrstuhl für Bioinformatik, Universität Leipzig, Leipzig, Germany.  Supervisor:  Prof. Peter Stadler.

Publications:
Conant, G. C. and K. H. Wolfe, (2008) Probabilistic cross-species inference of orthologous genomic regions created by whole-genome duplication in yeast, Genetics, 179: 1681-1692.
Powell, A. J., G. C. Conant, D. E. Brown, I. Carbone and R. A. Dean, (2008) Altered patterns of gene duplication and differential gene gain and loss in fungal pathogens, BMC Genomics, 9: 147.
Conant, G. C. and K. H. Wolfe, (2008) GenomeVx: Simple web-based creation of editable circular chromosome maps, Bioinformatics, 24: 861-862.
Conant, G. C. and K. H. Wolfe, (2007) Increased glycolytic flux as an outcome of whole-genome duplication in yeast,  Molecular Systems Biology, 3: 129.
Scannell, D. R., A. C. Frank, G. C. Conant, K. P. Byrne, M. Woolfit and K. H. Wolfe, (2007) Independent sorting-out of thousands of duplicated gene pairs in two yeast species descended from a whole-genome duplication, Proceedings of the National Academy of Sciences, U.S.A., 104: 8397-8402.
Conant, G. C., G. P. Wagner, and P. F. Stadler, (2007) Modeling amino acid substitution patterns in orthologous and paralogous genes, Molecular Phylogenetics and Evolution, 42: 298-307.
Conant, G. C. and K. H. Wolfe, (2006) Functional partitioning of yeast co-expression networks after genome duplication, PLoS Biology, 4:e109.
Conant, G. C. and A. Wagner, (2005) The rarity of gene shuffling in conserved genes, Genome Biology, 6:R50.
Babu, S. R., G. C. Conant, E. Eller, C. M. Roberts, K. Gowan, G. S. Eisenbarth, P. R. Fain, and P. Vardi, (2004)  A second-generation genome screen for linkage to Type 1 diabetes in a Bedouin Arab family, Annals of the New York Academy of Sciences, 1037: 157-160.
Conant, G. C. and A. Wagner, (2004) A fast algorithm for determining the best combination of local alignments to a query  sequence, BMC Bioinformatics, 5: 62.
Hahn, M. W., G. C. Conant, and A. Wagner, (2004) Molecular evolution in large genetic networks: Does connectivity equal constraint?  Journal of Molecular Evolution, 58: 203-211.
Conant, G. C. and A. Wagner, (2004) Duplicate genes and robustness to transient gene knockouts in Caenorhabditis elegans, Proceedings of the Royal Society, Biological Sciences, 271: 89-96.
Conant, G. C. and A. Wagner, (2003) Asymmetric sequence divergence of duplicate genes, Genome Research, 13: 2052-2058.
Conant, G. C., S. J. Plimpton, W. Old, A. Wagner, P. R. Fain, T. R. Pacheco, and G. Heffelfinger. (2003). Parallel Genehunter: Implementation of a linkage analysis package for distributed-memory architectures,  Journal of Parallel and Distributed Computing, 63: 674-682.
Conant, G. C. and A. Wagner, (2003) Convergent evolution of gene circuits, Nature Genetics, 34: 264-266.
Conant, G. C. and A. Wagner. (2002) GenomeHistory: A software tool and its application to fully sequenced genomes, Nucleic Acids Research, 30: 3378-3386.
Conant, G. C. and P. O. Lewis.  (2001) Effects of nucleotide composition bias on the success of the parsimony criterion in phylogenetic inference, Molecular Biology and Evolution, 18: 1024-1033.

Funding and awards

Department of Energy Computational Sciences Graduate Fellowship (2000-2004).  Included research practicum at Sandia National Laboratories (Alb.), Summer 2002.
Albuquerque High Performance Computing Center, Research Assistant (1998-2000)
Phi Beta Kappa, The University of New Mexico, 1998

Invited Seminars:

“Implications of whole-genome duplication on the ecological niche of Saccharomyces cerevisiae.” Biological Networks III: Modularity
and Genome Evolution, Bertinoro Italy, 2006

“Modeling gene order evolution after a genome duplication in yeast.”  Department of Plant Systems Biology, Ghent University, 2006